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Knee Replacement

Alternatives to Knee Replacement: My Honest Take on Each

Medically reviewed by Matthew Harb, M.D.Updated October 20, 20267 min read

Most people with knee arthritis never need a knee replacement, and those who do usually try other things first. Here is every alternative patients ask me about, what I think of each, and the order I actually use them in.

Key takeaways

  • The best alternatives are the simplest: therapy, medication, bracing, and injections (cortisone, gel, or PRP).
  • For arthritis on one side of the knee, an osteotomy or a partial knee replacement are real, proven options.
  • Nerve ablation (RFA) can help chronic pain or patients who can’t have surgery, but it isn’t a long-term treatment for arthritis.
  • I have real concerns about the knee spring (MISHA), the coral implant, and artery embolization (GAE), and they’re worth discussing in person.
  • Nothing available regrows cartilage. The right choice depends on your knee, and that starts with an exam and X-rays.

Nobody wants a knee replacement if something else will do. Patients come to me having read about injections, nerve procedures, implants, and cartilage “regrowth,” and they want to know what’s real. Here is my honest take on each, in the order I actually use them.

What I recommend first

The simplest treatments are the most important ones, and most patients start here:

  • Physical therapy to strengthen the muscles that support the knee.
  • Medication, such as acetaminophen or an anti-inflammatory, when it’s safe for you. See arthritis medications.
  • Bracing for support during activity.
  • Activity changes and, where it applies, weight loss, which takes load off the knee with every step.

Injections

When the simple steps aren’t enough, injections are next.

  • Cortisone: calms a flare quickly. Relief varies from person to person.
  • Gel (hyaluronic acid): a lubricating injection for the knee, often covered by insurance.
  • PRP: made from your own blood. I offer it for the right patient with mild to moderate arthritis. It doesn’t regrow cartilage, but it can help pain.

Not sure which fits? See my guide to injection options. If you’ve read about stem cell injections, I cover those in stem cell injections and other regenerative treatments.

Smaller surgeries

For arthritis mostly on one side of the knee, there are two proven options short of a total knee replacement:

  • Knee osteotomy: the bone is cut and realigned so your weight shifts away from the worn side. It’s best suited to younger, active patients with the right alignment.
  • Partial knee replacement: replaces only the worn part and keeps the rest of your own knee. For the right knee, it does the job, with decades of results behind it.

Wondering whether a scope can clean out an arthritic knee? Usually not; see do you need a knee scope?

Pain procedures

These quiet the pain signal from the knee. They don’t change the joint.

  • Radiofrequency ablation (RFA): a needle uses heat to quiet the small nerves that carry pain from the knee. I sometimes send patients for it, usually for chronic pain, or when someone isn’t a candidate for surgery. The arthritis is still there, so I see it as a pain treatment rather than a long-term answer.
  • Iovera (nerve freezing): uses cold instead of heat on the same kind of nerves. Some surgeons have used it before knee replacement to ease recovery. In my view, that hasn’t panned out the way people hoped.

Newer options I have concerns about

These get a lot of attention online. Each has its own page with my full reasoning:

Anything that regrows cartilage?

Not in a knee with arthritis, whether it’s an injection, a gel, or a supplement. I explain why in can you regrow cartilage in your knee or hip?

When replacement is the answer

When the knee keeps limiting your life despite these treatments, a knee replacement is the lasting answer. It isn’t about a particular age or a single X-ray. For how to tell, see bone-on-bone knee: do I need surgery?

Bring your list

If you’ve been researching options, bring your list to your visit. We’ll go through it together with your X-rays, and I’ll tell you what I would do in your place.

I see patients in Washington, D.C. and Germantown, Maryland. Request an appointment.

This article is general education and reflects my professional opinion. It isn’t advice about your specific knee.

Frequently asked questions

What is the best alternative to knee replacement?

For most people, a combination of physical therapy, medication, bracing, and injections, used step by step. For arthritis on one side of the knee, an osteotomy or a partial knee replacement can also be good options. Which is best depends on your X-rays, your symptoms, and your goals.

What is the newest alternative to knee replacement?

Patients ask me about the knee spring (MISHA), the coral implant (CartiHeal Agili-C), and genicular artery embolization (GAE). Newer doesn’t always mean better. I have concerns about each, which I explain on each one’s page, and I’m happy to talk them through with you.

Does radiofrequency ablation work for knee arthritis?

It can reduce pain for a while by quieting the nerves that carry pain from the knee. I sometimes send patients for it, usually for chronic pain or when someone isn’t a candidate for surgery. It doesn’t treat the arthritis, so it isn’t a long-term answer.

Is a partial knee replacement an alternative to a total knee?

Yes, for the right knee. If the arthritis is limited to one part of the knee, a partial replaces only that part and keeps the rest of your own knee. Not every knee qualifies.

How long can I put off a knee replacement?

As long as the simpler treatments keep you doing what you want to do. The time to consider surgery is when the knee keeps limiting your life despite them, not a particular age or X-ray finding.

References

  1. AAOS OrthoInfo — Arthritis of the Knee
  2. FDA — De Novo DEN220033: MISHA Knee System (April 2023)
  3. Genicular artery embolization for knee osteoarthritis: a systematic review of sham-controlled randomized trials (PMC)

This article is for general education and is not a substitute for personalized medical advice. Recovery timelines vary by patient, procedure, medical history, and surgeon-specific protocol. Please consult Matthew Harb, M.D. about your specific condition.

Patient experiences

What patients say

“A really smooth operation — I was discharged the same day and basically able to walk easily within a day.”
Mark T.Hip replacement
“I walked into the surgical center in great pain and walked out with a new knee and a renewed person.”
Brian K.Knee replacement
“My full knee replacement is a big success — six months after surgery I’m hiking and kayaking again.”
Lynn H.Knee replacement
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